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Tizanidine

Tizanidine 2mg, 4mg, 6mg

Tizanidine is a muscle relaxant prescribed to alleviate muscle spasms and associated pain by acting on the central nervous system to inhibit nerve signals. Commonly used for conditions such as multiple sclerosis or spinal cord injuries, it provides relief from muscle tightness, enhancing mobility and comfort. Tizanidine may cause drowsiness, so caution is advised when operating machinery or driving.

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Description

Tizanidine is a short-acting muscle relaxant that is used to treat muscle spasms and associated pain. It works by blocking nerve impulses that are sent to the brain, helping to relieve tightness and discomfort in muscles.

Uses / Indications

  • Muscle spasticity due to multiple sclerosis or spinal cord injury
  • Management of muscle spasms
  • Relief of associated pain and discomfort
  • Adjunctive therapy for acute musculoskeletal pain

Dosage and Administration

Adults:
The typical starting dose is 2 mg taken at bedtime. The dose may be increased gradually, based on effectiveness and tolerability, to a maximum dose of 36 mg per day.

Older adults:
A lower starting dose may be recommended due to increased sensitivity to side effects.

Note: Dosage may vary based on individual medical conditions and doctor’s advice.

How It Works (Mechanism of Action)

Tizanidine is an alpha-2 adrenergic agonist that works by inhibiting presynaptic release of excitatory neurotransmitters in the spinal cord. This mechanism leads to a reduction in muscle tone and helps alleviate muscle spasms without causing significant sedation.

Side Effects

Common side effects:

  • Drowsiness
  • Dry mouth
  • Weakness or fatigue
  • Dizziness

Rare/serious side effects:

  • Low blood pressure or fainting
  • Severe allergic reactions (rash, itching, swelling)
  • Liver function abnormalities (hepatic impairment)

Seek medical attention if serious side effects occur.

Precautions / Warnings

  • Inform your doctor if you have liver disease or a history of hypotension
  • Use caution when driving or operating machinery until you know how Tizanidine affects you
  • Regular monitoring of liver function tests may be required during treatment

Drug Interactions

Tizanidine may interact with:

  • Ciprofloxacin and other CYP1A2 inhibitors (may increase Tizanidine levels)
  • Clonidine (may potentiate hypotensive effects)
  • Oral contraceptives (may reduce Tizanidine effectiveness)
  • Alcohol (may enhance sedative effect)

Always inform your healthcare provider about any other medications or supplements you are taking.

Storage Instructions

  • Store at room temperature (15°C–30°C / 59°F–86°F)
  • Keep away from moisture, heat, and light
  • Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s close to the time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

  • Severe drowsiness
  • Slow heartbeat
  • Low blood pressure
  • Confusion

Contact a poison control center or seek emergency medical help immediately.

Contraindications

  • Allergic to Tizanidine or any of its ingredients
  • Concomitant use with potent CYP1A2 inhibitors

Brand Names / Alternatives

  • Zanaflex
  • Generic name: Tizanidine