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Sulfasalazine

Sulfasalazine 500mg, 1000mg

Sulfasalazine is a medication primarily used to treat inflammatory bowel diseases such as ulcerative colitis and Crohn’s disease, as well as rheumatoid arthritis. It works by reducing inflammation in the intestines and joints, helping to alleviate symptoms such as abdominal pain and joint swelling. Sulfasalazine contains a combination of sulfa and salicylate components, which together contribute to its anti-inflammatory effects, making it a vital option for managing these chronic conditions.

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Description

Sulfasalazine is a prescription medication classified as a disease-modifying antirheumatic drug (DMARD) that is primarily used to treat inflammatory bowel disease (IBD) and rheumatoid arthritis. It works by reducing inflammation in the body, providing relief from the symptoms associated with these conditions.

Uses / Indications

  • Rheumatoid arthritis
  • Ulcerative colitis
  • Crohn’s disease
  • Ankylosing spondylitis
  • Junctional inflammatory bowel disease
  • Eases joint pain and swelling

Dosage and Administration

Adults:
The typical starting dose is 500 mg to 1000 mg taken orally twice daily, which may be adjusted by your healthcare provider based on response and tolerance.

Children:
Dosage is usually based on body weight and should be determined by a healthcare professional.

Note: Always follow your doctor’s instructions regarding dosage and administration.

How It Works (Mechanism of Action)

Sulfasalazine is believed to work by inhibiting the inflammatory process in the intestines and joints. It is metabolized in the body into sulfapyridine and 5-aminosalicylic acid (5-ASA), both of which contribute to reducing inflammation.

Side Effects

Common side effects:

  • Nausea
  • Headaches
  • Abdominal pain or discomfort
  • Skin rashes

Rare/serious side effects:

  • Severe allergic reactions (rash, itching, swelling)
  • Liver problems (elevated liver enzymes)
  • Blood disorders (low blood cell counts)

Seek immediate medical attention if you experience serious side effects.

Precautions / Warnings

  • Inform your doctor if you have allergies to sulfa drugs or aspirin.
  • Use with caution if you have liver disease, kidney problems, or a history of blood disorders.
  • Regular blood tests may be required to monitor your condition and adjust your dosage.

Drug Interactions

Sulfasalazine may interact with:

  • Medications that affect blood clotting (e.g., warfarin)
  • Other medications used to treat rheumatoid arthritis
  • Antibiotics
  • Medications that impact liver enzymes

Always inform your healthcare provider of any other medications or supplements you’re taking.

Storage Instructions

  • Store at room temperature (20°C–25°C / 68°F–77°F)
  • Keep away from heat, moisture, and direct light
  • Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double the dose.

Overdose symptoms:

  • Severe nausea or vomiting
  • Dizziness
  • Confusion
  • Severe headache

Contact a poison control center or seek emergency medical help immediately if an overdose is suspected.

Contraindications

  • Allergy to sulfasalazine or any component of the drug
  • History of blood disorders or severe kidney issues

Brand Names / Alternatives

  • Azulfidine
  • Generic name: Sulfasalazine